If you want to include dosing information while fitting a model to data, the dosing information must be specified in the data not in the model. If you add doses to the model, they are ignored during fitting tasks. The dosing specified in the data is applied in an additive fashion, including at the start of the simulation. Therefore, ensure that you set the Initial Amount of a species to the value before any dosing is applied.
The steps for fitting a model to data containing dosing information are as follows:
1) Go to Project => Data => Your experimental data set => Raw Data
2) Ensure that the column with the dosing information is set to dose1 from the drop down menu. If there are several doses set the other doses to dose2 and so forth
3) At time points at which there is no dosing set the value of the dose to NaN
4) Go to Project => Tasks => Fit Data => Dosing Information
5) Click on Edit
6) Enter the name of the column which contains the dosing information as Dose Column Name
7) Enter the name of the component that is going to change directly due to the dose as Dose Component Name.
8) Enter the Dose Configuration (bolus in most cases)
